The Diabetic Platelet

Patients with Diabetes Mellitus (DM) have accelerated atherosclerosis, which is the main essential factor contributing to high risk of atherothrombotic events in these patients. Atherothrombotic complications are principal cause morbidity and mortality patients DM. Both atherosclerosis increased thrombotic vascular may result from dyslipidaemia, endothelial dysfunction, platelet hyperreactivity, an impaired fibrinolytic balance, abnormal blood flow. Platelets DM characterised by dysregulation several signalling pathways causing adhesion, activation aggregation. Platelet function complicated mechanisms, such as hyperglycaemia, insulin deficiency resistance, associated metabolic conditions, cellular abnormalities. The present manuscript purposes provide a review on up-to-date status data abnormalities that characterise